Comparison of Prophylaxis and On-demand Treatment in Children With Moderate to Severe Hemophilia A

Chulalongkorn University

Status: Completed

Conditions: Prophylaxis; Hemophilia A

Treatments: Other: prophylaxis treatment, on demand treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT02362581

3125055

Details and patient eligibility

About

Comparison of prophylaxis and on-demand treatment in children with moderate to severe hemophilia A.

This study determines to compare the efficacy of prophylaxis and on-demand treatment in moderate to severe hemophilia A children in King Chulalongkorn Memorial Hospital, Bangkok, Thailand

Enrollment: 15 patients

Sex: All

Ages: 6 months to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 6 months to 18 years
• Diagnosis severe and moderate hemophilia A

Exclusion criteria

• platelet < 100,000/mm3
• No factor VIII inhibitor

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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15 participants in 1 patient group

On demand treatment, prophylaxis treatment

Experimental group

Description:

On demand treatment arm:Patients received factorVIII concentrate(Hemofil M) when they had bleeding episodes. Prophylaxis arm: patients received factorVIII concentrate (Hemofil M) 30-35 unit/kg once a week

Treatment:

Other: prophylaxis treatment, on demand treatment