Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Medical University of South Carolina (MUSC) logo

Medical University of South Carolina (MUSC)

Status

Completed

Conditions

Atrial Fibrillation

Treatments

Drug: propofol
Drug: sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02697448
Pro00044072

Details and patient eligibility

About

Comparison of propofol and sevoflurane as a primary anesthetic for cardiac ablation of atrial fibrillation

Full description

A side effect of some volatile anesthetics, such as isoflurane and desflurane, is enhanced automaticity, accounting for secondary atrial pacemakers. Volatile anesthetics also have varying effects on the AV node and His-Pukinje system. These agents also prolong the QT interval and, for this reason, volatile anesthetics as a group have at times been avoided for atrial fibrillation ablation due to the fear that they may affect the efficacy of the ablation and increase recurrence. However, sevoflurane does not have the effects shown for other volatile anesthetics cardiac conduction. At this point there has not been a study comparing propofol, a non volatile anesthetic typically used in these cases, to sevoflurane, a volatile anesthetic, to determine if volatile anesthetics should be avoided during these procedures. This study will challenge the existing belief that sevoflurane increases the length of time to ablate atrial fibrillation and also decreases the efficacy of the ablation.

Enrollment

134 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • have paroxysmal atrial fibrillation
  • undergoing their first ablation.

Exclusion criteria

  • none

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

134 participants in 2 patient groups

propofol
Active Comparator group
Description:
Participants receiving propofol as anesthetic for cardiac ablation.
Treatment:
Drug: propofol
sevoflurane
Active Comparator group
Description:
Participants receiving sevoflurane as anesthetic for cardiac ablation.
Treatment:
Drug: sevoflurane

Trial contacts and locations

1

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Central trial contact

Haley Nitchie; Ross Glennda

Data sourced from clinicaltrials.gov

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