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Comparison of Propofol and Sevoflurane as Maintaining Anesthetics During General Anesthesia of Cesarean Section

T

Tao Zhang

Status and phase

Unknown
Phase 4

Conditions

Cesarean Section
Propofol
Sevoflurane

Treatments

Drug: sevoflurane
Drug: propofol

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Sevoflurane and propofol are the most popular drug choices for maintenance of general anaesthesia for caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly. The aim of this study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia, and to try to determine which anesthetic is better for maternal and fetal outcomes after caesarean section.

Full description

General anaesthesia is mostly performed for emergency grade 1 caesarean section and due to a lack of time to apply a neuraxial anaesthesia technique. Rapid sequence induction using propofol and rocuronium should become the standard for general anaesthesia in the obstetric patient. Both sevoflurane and propofol are considered to be appropriate for the maintenance of general anaesthesia during caesarean section. However, effects of these two anesthetics on maternal and fetal outcomes after caesarean section haven't been compared directly in the past. And for most anaesthesiologists, the clinical experience with general anaesthesia for caesarean section is very low. This study is to compare the effects of sevoflurane and propofol as maintenance of general anesthesia.

Enrollment

60 estimated patients

Sex

Female

Ages

18 to 35 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASAⅠor Ⅱ parturients (aged 18-35 years) undergoing elective caesarean section

Exclusion criteria

  • Parturients with severe pregnancy complications

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

propofol
Experimental group
Treatment:
Drug: propofol
sevoflurane
Experimental group
Treatment:
Drug: sevoflurane

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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