Comparison of Propofol Based Versus Volatile Based Anesthesia and Postoperative Sedation

University Health Network, Toronto

Status

Completed

Conditions

Cardiac Surgery

Treatments

Other: Propofol

Drug: Isoflurane/sevoflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT01151254

UHN REB 06-0159 B

Details and patient eligibility

About

All patients undergoing cardiac surgery require intraoperative anesthesia and short-term postoperative sedation with anesthetic agents after the procedure when patient is in the intensive care unit (ICU). The clinical data obtained so far are concentrating on intraoperative use volatile agents (preconditioning) resulting in better postoperative cardiac function and less release of biochemical markers of myocardial damage. There are no studies investigating whether postoperative use of volatile agents (post conditioning) in cardiac surgical population is improving outcomes. The aim of the present study is to compare total intravenous anesthesia and postoperative sedation versus total volatile anesthesia and postoperative sedation in cardiac surgical population.

Enrollment

146 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients scheduled for coronary artery bypass graft surgery with good ventricular function (grade 1-2 ventricle)
Signed informed consent

Exclusion criteria

Patients undergoing valvular surgery
Severe kidney or liver disease (creatinine > 2.5mg.dL-1 and bilirubin > 2 mg.dL-1)
Patients with known hypersensitivity to any of the trial drugs (propofol, volatile anesthetics), e.g. propofol allergy or malignant hyperthermia (induced by volatile anesthetics)
Patient with poorly controlled diabetes or on oral anti-diabetic medication (inhibit preconditioning caused by volatile anesthetics)