Comparison of PRP & DFDBA vs. DFDBA in Intrabony Periodontal Defects

Government Dental College and Hospital, India

Status: Completed

Conditions: Chronic Periodontitis

Treatments: Other: PRP combined with DFDBA; Other: DFDBA

Study type: Interventional

Funder types: Other

Identifiers

NCT05886699

PMeshram

Details and patient eligibility

About

The purpose of this clinical trial is to compare the results in subjects with periodontitis using subjects own blood - Platelet-rich plasma (PRP) combined with bone graft material, namely, Demineralized Freeze - Dried Bone Allograft (DFDBA) or DFDBA alone in the treatment of bone defects around the teeth.

Full description

After being informed about the study and potential risks, 13 patients giving written informed consent and who meet the eligibility requirements were randomly allocated in a single blind manner (participants) to test group (PRP combined with DFDBA) or control group (DFDBA).

33 sites (18 test, 15 control unpaired defects) were treated - 1) to investigate the possible additional effects of PRP when combined with DFDBA, and 2) to compare the clinical and radiographic outcomes obtained in test and control groups,12 months post - operatively.

Enrollment: 13 patients

Sex: All

Ages: 28 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Outpatients
• with chronic periodontitis
• who were free of local or systemic disease
• who had not received any type of periodontal therapy in the last six months
• radiograph showing at least one angular defect in any quadrant
• the involved teeth were vital and asymptomatic
• the site of interest had at least 2 mm of keratinized gingiva on the facial aspect of the selected teeth

Exclusion criteria

• Patients with abnormal platelet count
• allergic to chlorhexidine or any other medicine used in the study
• showing unacceptable oral hygiene compliance during / after the phase I therapy;
• pregnant or lactating mothers;
• smokers
• endodontically involved teeth
• patients under any medication known to interfere with periodontal healing. e.g., corticosteroids
• on anticoagulant therapy
• patients with transferable jobs or who were uncooperative
• patients participating in other dental clinical trials.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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13 participants in 2 patient groups

PRP combined with DFDBA

Experimental group

Description:

Open flap debridement, followed by placement of PRP combined with DFDBA

Treatment:

Other: PRP combined with DFDBA

DFDBA

Active Comparator group

Description:

Open flap debridement, followed by placement of DFDBA

Treatment:

Other: DFDBA