Comparison of Quadratus Lumborum Block With TAP Block for Postoperative Analgesia After Laparoscopic Nephrectomy

Post Graduate Institute of Medical Education and Research, Chandigarh

Status: Completed

Conditions: Postoperative Pain

Treatments: Other: Transversus Abdominis Plane (TAP) Block; Other: Quadratus Lumborum (QL) Block

Study type: Interventional

Funder types: Other

Identifiers

NCT02824939

NK/2663/MS/3121-22

Details and patient eligibility

About

This is a randomised controlled trial which will compare the Quadratus Lumborum (QL) Block with the Transversus Abdominis Plane (TAP) Block in terms of analgesic efficacy, ease of performance and safety when administered postoperatively in patients who undergo laparoscopic nephrectomy.

To fulfill this purpose, three groups of patients each with 32 patients, will be formed. Patients in the Transversus Abdominis Plane (TAP) group and Quadratus Lumborum (QL) group will each receive the respective blocks with 0.4 ml/kg of 0.25% Bupivacaine, after completion of surgery. The third (Control group) will not receive any blocks. After shifting patients to recovery all three groups will be put into intravenous patient controlled analgesia (PCA) Morphine as rescue analgesic regimen as per a set protocol. Morphine consumption over the first postoperative 24 hours, ease of performance of individual blocks and associated adverse events, adverse events associated with opioid use, patient recovery and satisfaction will be noted.

Enrollment: 96 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients between 18-65 years of age,
• ASA class I or II,
• undergoing elective unilateral laparoscopic nephrectomy
• under general anaesthesia

Exclusion criteria

Patients with any of the following:

• refusal to participate in the study
• coagulopathy/ thrombocytopenia
• localised infection at the proposed site of injection
• inability to comprehend the scoring systems to be employed or use PCA due to physical or mental problems
• known allergy to the drugs to be used (local anesthetics, opioids)
• opioid tolerance/ dependence
• renal impairment
• hepatic impairment
• known cardio-respiratory impairment
• morbid obesity/ sleep apnoea

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

96 participants in 3 patient groups

Transversus Abdominis Plane group

Experimental group

Treatment:

Other: Transversus Abdominis Plane (TAP) Block

Quadratus Lumborum group

Experimental group

Treatment:

Other: Quadratus Lumborum (QL) Block

Control group

No Intervention group