Comparison of Remimazolam and Propofol Effect on Oxygenation Reservoir During Diagnostic Gastric Endoscopy

Yonsei University

Status: Completed

Conditions: Diagnostic Gastric Endoscopy

Treatments: Drug: Propofol; Drug: Remimazolam besylate

Study type: Interventional

Funder types: Other

Identifiers

NCT05723627

4-2022-1369

Details and patient eligibility

About

Propofol is one of the most commonly used sedative in endoscopic procedures, while its potency to induce respiratory depression may threaten patient safety. Remimazolam is known to less likely induce hemodynamic instability when compared to propofol, yet its favorable effects are not clearly evaluated in endoscopic procedures. Hence, this study aimed to compare hemodynamic effects of remimazolam and propofol, by evaluating oxygen reserve index (ORI) in patients scheduled for diagnostic gastric endoscopy.

Enrollment: 70 patients

Sex: All

Ages: 19 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients (age 19~80 yrs, ASA Class I~III, ECOG 0~1) who are scheduled for elective diagnostic gastric endoscopy

Exclusion criteria

Pregnancy Allergy to remimazolam or propofol Underlying pulmonary diseases or obstructive sleep apnea Hypotension (SBP <80mmHg) or hypoxemia (SpO2 <90%) assessed prior to procedure

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups

Remimazolam

Experimental group

Description:

Patient group who receives remimazolam for sedation during endoscopy

Treatment:

Drug: Remimazolam besylate

Propofol

Active Comparator group

Description:

Patient group who receives propofol for sedation during endoscopy

Treatment:

Drug: Propofol