Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Johns Hopkins University

Status and phase: Completed; Phase 2

Conditions: Wrinkles; Photodamaged Skin

Treatments: Drug: Retinol; Drug: Tretinoin

Study type: Interventional

Funder types: Other

Identifiers

NCT01283464

SKM10-R-01

Details and patient eligibility

About

The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Enrollment: 24 patients

Sex: All

Ages: 35+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 35 or over
• Moderate to severe photodamage

Exclusion criteria

• History of facial cosmetic surgery, facial resurfacing procedures, deep peels, or facial fillers
• History of keloids or hypertrophic scars
• Use of oral steroids or oral retinoids (such as Accutane) in past 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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24 participants in 2 patient groups

Retinol

Active Comparator group

Description:

Retinol 1.0% cream

Treatment:

Drug: Retinol

Tretinoin

Active Comparator group

Description:

Tretinoin 0.02% cream

Treatment:

Drug: Tretinoin