Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels

Ege University

Status

Enrolling

Conditions

Saliva

Procalcitonin

Children, Only

Bacterial Infections

Treatments

Diagnostic Test: Sliva Procalcitonin

Study type

Interventional

Funder types

Other

Identifiers

NCT06354205

24-3.1T/98

Details and patient eligibility

About

Recently, it has been seen that investigations from saliva samples could be an alternative to those from blood samples. Saliva collection is a simple, non-invasive, cost-effective, and relatively easy method, making it potentially suitable as a new diagnostic tool in pediatric patients. In the current literature, elevated levels of saliva CRP, TNF-α, IL-6, and IFN-γ have been reported in inflammatory conditions. However, while there are animal studies suggesting the use of saliva PCT levels for focal diseases such as gingival inflammation and periodontitis and as a potential tool for non-invasive detection of sepsis, there is no human study regarding its use in systemic infections.

The aim of this study is to evaluate the correlation between serum PCT levels and saliva PCT levels in children suspected of SBE and to determine the diagnostic value of saliva PCT.

Enrollment

160 estimated patients

Sex

All

Ages

Under 1 year old

Volunteers

No Healthy Volunteers

Inclusion criteria

Being under one year of age
Having serum Procalcitonin (PCT) requested due to suspicion of systemic infection

Exclusion criteria

Being over one year of age
Having a chronic illness that could cause elevation in inflammatory biomarkers
Taking any medication (such as antibiotics, immunomodulatory, or immunosuppressive drugs, etc.) that could affect inflammatory biomarkers
Diagnosis of gingivostomatitis