Comparison of Serum Calcium Level Between Preoperative Vitamin D and Non-vitamin D Regimen of Total Parathyroidectomy in End-stage Renal Failure Patients in Rajavithi Hospital

Rajavithi Hospital

Status: Completed

Conditions: End Stage Renal Disease

Treatments: Drug: Calcitriol; Drug: Alfacalcidol 0.5 MCG Oral Capsule

Study type: Interventional

Funder types: Other

Identifiers

NCT04967469

63127

Details and patient eligibility

About

This Research is compare about IV Calcium between end-stage renal failure patients who take vitamin D and non-vitamin D preoperative parathyroidectomy

Enrollment: 60 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• New End-stage renal failure patients and have iPTH>800 pg/dl at least 6 months
• Patients who no response hyperphosphatemia with high dose vitamin D

Exclusion criteria

• Allergy vitamin D
• Pregnancy
• Patients who parathyroidectomy have less than 4 gland

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

take calcitriol

Experimental group

Description:

End-stage renal failure patients who is Hyperparathyroid with ESRD take calcitriol

Treatment:

Drug: Calcitriol

take alphacalcidol

Experimental group

Description:

End-stage renal failure patients who is Hyperparathyroid with ESRD take 1-hydroxycholecalciferol (alfacalcidol)

Treatment:

Drug: Alfacalcidol 0.5 MCG Oral Capsule

control

No Intervention group

Description:

End-stage renal failure patients who is Hyperparathyroid with ESRD take standard treatment