Comparison of Serum Trefoil Factor 3 in Patients With Gingivitis and Periodontitis After Scaling and Root Planing (CSTF3PGPSR)

Dr.K.Sai Priyanka

Status: Completed

Conditions: Gingivitis and Periodontal Diseases

Treatments: Procedure: Scaling and root planing

Study type: Interventional

Funder types: Other

Identifiers

NCT03620396

Panineeya Mahavidyalaya

D159206045 (Other Identifier)

Details and patient eligibility

About

This study is intended to measure serum trefoil factor 3 at baseline and 3 months after, following nonsurgical periodontal therapy in patients with Gingivitis and Chronic Periodontitis.

Full description

A goal of periodontal diagnostic procedure is to provide useful information to the clinician regarding the present periodontal disease type and severity. Advances in diagnostic research are moving towards methods where periodontal risk can be identified and quantified by objective measures such as Biomarkers.

Trefoil factors (TFFs) are one such secreted molecules derived from mucin producing epithelial cells of the gastro intestinal tracts and other tissues such as Salivary glands, Parotid ducts and oral mucosa. Among three Trefoil factors reported, Trefoil Factor 3 (TFF3) is the modifying factor for signalling pathway involved in cell survival, cell proliferation and cell migration of oral keratinocytes. Hence assessing the marker levels would achieve beneficial effects on diagnosing the disease severity.

Enrollment: 40 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

For Gingivitis:

• Gingival Index: 1.1 to 2.
• Modifies Plaque Index: 1.0 to 1.9

For Periodontitis:

• Gingival Index: 1.1 to 2.
• Modifies Plaque Index: 1.0 to 1.9
• Probing depth > 4mm
• Clinical attachment loss > 2mm

Exclusion criteria

For Gingivitis:

• Presence of gingival recession.
• Presence of clinical attachment loss.
• Presence of furcation.
• Presence of systemic infections like diabetes, infections.
• Smokers.
• Antibiotic therapy received preceding 3 months.
• Patients who underwent periodontal therapy within 3 months.
• Pregnant and Lactating women.

For Periodontitis:

• Presence of any systemic conditions like diabetes, infections.
• Smokers.
• Antibiotic therapy received preceding 3 months.
• Patients who underwent periodontal therapy within 3 months.
• Pregnant and Lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Experimental: Interventional

Experimental group

Description:

Group A patients consists of Gingivitis patients whose serum is collected at base line and treated with Scaling and root planing and after three months serum is collected for assessment of Trefoil factor 3.

Treatment:

Procedure: Scaling and root planing

Experimental Interventional

Experimental group

Description:

Group B patients consists of Periodontitis patients whose serum is collected at base line and treated with Scaling and Root Planing and after three months serum is collected for assessment of Trefoil factor 3.

Treatment:

Procedure: Scaling and root planing