Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow Rates

Laval University

Status: Not yet enrolling

Conditions: Respiratory Failure; Oxygen Toxicity; COPD Bronchitis

Treatments: Device: Nasal canula - up to 15 liters per minute; Device: Nasal canula - up to 6 liters per minute; Device: Simple oxygen face mask; Device: Open oxygen mask

Study type: Interventional

Funder types: Other

Identifiers

NCT06646991

2025-4198

Details and patient eligibility

About

Oxygen therapy is at the heart of the healthcare system. Oxygen flow rates depend on a number of confounding factors confounding factors (target used, skin pigmentation, pulse oximeter used, etc.) The investigators have recently have recently demonstrated that the combination of these factors (different peripheral oxygen saturation (SpO2) targets and different oximeters) can have a significant impact on oxygen flows rates. The effect on oxygen flow was not simply additive .

The aim of this study is to evaluate the impact of the interface used on oxygen flow rates in different patient populations (main objective). The investigatoers also evaluate the impact of the interface on carbon dioxide (PaCO2), in particular with closed oxygen masks, with which rebreathing is theoretically possible (secondary objective).

secondary objective).

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (> or = 18 years old)
• Ongoing on conventional oxygen therapy with peripheral oxygen saturation (SpO2) between 88 and 100% with the usual oximeter
• SpO2 < 92% ambient air with the usual oximeter

Exclusion criteria

• No SpO2 signal with with the usual oximeter
• False nails or nail polish
• Severe anemia documented on last blood count during current hospitalization (haemoglobin (Hb) < 80g/L)
• Oxygen flow > 6 L/min

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Nellcor oximeter

Other group

Treatment:

Device: Simple oxygen face mask

Device: Open oxygen mask

Device: Nasal canula - up to 6 liters per minute

Device: Nasal canula - up to 15 liters per minute

Nonin Oximeter

Other group

Treatment:

Device: Nasal canula - up to 6 liters per minute