Comparison of Side Effects of Morphine and Hydromorphone Patient-Controlled Analgesia (PCA)

Columbia University

Status and phase: Completed; Phase 4

Conditions: Post Operative Pain

Treatments: Drug: Hydromorphone PCA; Drug: Morphine PCA

Study type: Interventional

Funder types: Other

Identifiers

NCT00385541

AAAA2949

Details and patient eligibility

About

Both morphine and hydromorphone are pain medications commonly used after surgery. It is thought at the institution that hydromorphone causes less side effects but this has not been studied. The study proposes to treat the patients with either morphine or hydromorphone and determine how much nausea, vomiting, and itching they have with each drug

Enrollment: 50 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled for abdominal surgery requiring post-operative PCA
• ASA = I or II

Exclusion criteria

• preoperative pain or use of pain medication
• narcotic allergy
• morbid obesity (Body Mass Index > 30)
• diagnosis of sleep apnea
• hepatic or renal disease
• use of medications that would affect narcotic pharmacodynamics
• preoperative nausea, vomiting, or pruritis
• diagnosis of alcoholism

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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50 participants in 2 patient groups

A

Active Comparator group

Description:

Patients receive morphine 1mg/dose PCA for postsurgical pain; max 10 mg/hr; lockout 6 minutes.

Treatment:

Drug: Morphine PCA

B

Active Comparator group

Description:

Patients receive hydromorphone 0.2mg/dose PCA for postsurgical pain; max 10mg/hr; lockout 6 minutes.

Treatment:

Drug: Hydromorphone PCA