COMPARISON OF SILODOSIN AND TAMSULOSIN IN MEDICAL EXPULSIVE THERAPY OF DISTAL URETERIC CALCULI

Armed Forces Institute of Urology, Rawalpindi

Status and phase: Completed; Phase 1

Conditions: Silodosin, Tamsulosin, Medical Expulsive Therapy, Distal Ureteric Calculi

Treatments: Drug: Tamsulosin; Drug: Silodosin

Study type: Interventional

Funder types: Other

Identifiers

NCT05790902

AFIU-2022-02

Details and patient eligibility

About

to compare efficacy and safety of Silodosin and Tamsulosin in Medical expulsive therapy of Distal Ureteric Calculi.

Full description

to compare efficacy and safety of Silodosin and Tamsulosin in Medical expulsive therapy of Distal Ureteric Calculi in our local setup to find out the optimal drug which promptly and quickly cures the disease thus enabling the person to return to routine activity with less adverse effects.

Enrollment: 142 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• symptomatic, unilateral, single, uncomplicated Distal Ureteric Calculi of <10 mm in size (on plain CT KUB)

Exclusion criteria

• solitary kidney, bilateral ureteric stones, UTI, renal impairment, high-grade hydronephrosis (Grades 3 and 4), any history of previous endoscopic or surgical interventions, pregnancy, diabetes mellitus,

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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142 participants in 2 patient groups

Silodosin Group

Experimental group

Description:

The patients used Silodosin for ureteric calculi

Treatment:

Drug: Silodosin

Tamsulosin Group

Experimental group

Description:

The patients used Tamsulosin for ureteric calculi

Treatment:

Drug: Tamsulosin