Comparison of Six Different Machine Learning Methods With Traditional Model for Low Anterior Resection Syndrome After Minimally Invasive Surgery for Rectal Cancer -- Development and External Validation of a Nomogram : A Dual-center Cohort Study

Northern Jiangsu People's Hospital

Status: Completed

Conditions: LARS - Low Anterior Resection Syndrome; Rectal Cancer

Treatments: Procedure: Anastomotic leakage; Procedure: LCA Preserving; Behavioral: BMI; Procedure: nCRT; Procedure: Prophylactic stoma; Procedure: Surgical approach; Procedure: Surgical type; Diagnostic Test: Distance from AV

Study type: Observational

Funder types: Other

Identifiers

NCT07267767

jiangsuNorthen20

Details and patient eligibility

About

Following thorough screening based on inclusion and exclusion criteria, patients from the two sizable medical centers were split up into two cohorts for this study. Cohort 1 served primarily as the training and internal validation set, while Cohort 2 was used for external validation of the predictive model constructed from Cohort 1. We used six distinct machine learning methodss, including DT, RF, XGBOOST, SVM, lightGBM, and SHLNN, in addition to conventional logistic regression to create the predictive model. We chose the approach with the best sensitivity and specificity by comparing the concordance index(C-index) akin to the area under the ROC curve (AUC) of these seven distinct model-building methods. The predictive model for Cohort 1 was then built using this method, and internal validation was finished. Lastly, Cohort 2 underwent external validation of the predictive model

Enrollment: 3,500 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:(1) rectal adenocarcinoma (2) minimally invasive sphincter-preserving surgery (taTME/ISR/LAR) (3) intact baseline anal function (4) no emergent presentations or metastases.

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Exclusion Criteria:emergent presentations or metastases

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