Comparison of Skin Condition After Hyaluronic Acid Application on Dry vs. Moist Skin

University of Split

Status: Completed

Conditions: Skin Hydration; Hyaluronic Acid

Treatments: Other: Topical Hyaluronic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT07078474

2181-198-03-04-25-0064

Details and patient eligibility

About

This study aims to compare the effects of two different methods of applying hyaluronic acid (HA) on skin parameters in healthy individuals. HA is a widely used ingredient in skincare products due to its hydrating properties. However, it is unclear whether applying HA to dry or pre-moistened skin provides better results in terms of skin hydration and texture.

In this non-invasive, interventional trial, 23 healthy volunteers aged 18 to 50 will be randomly assigned to two groups. One group will apply HA to dry skin, while the other will apply HA to moistened skin. Skin parameters will be measured before and after the intervention to assess hydration, transepidermal water loss, and overall skin condition.

The aim is to determine the optimal method of HA application that maximizes its effectiveness in improving skin quality. Participants may benefit from improved skin hydration and increased awareness of the best application method for their skin type. No significant risks are expected from participation.

Enrollment: 23 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy individuals aged 18 to 50 years
• Willingness to apply the product daily for 3 weeks
• Ability to attend all scheduled skin assessments (baseline + weekly)
• Provided written informed consent

Exclusion criteria

• Known allergy or sensitivity to hyaluronic acid or any component of the product
• Active skin diseases or dermatological conditions in the facial area
• Use of systemic or topical corticosteroids or retinoids within 4 weeks prior to study
• Pregnancy or breastfeeding
• Participation in another clinical trial within the past 30 days

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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23 participants in 2 patient groups

Dry Skin Application

Experimental group

Description:

Participants in this group applied hyaluronic acid topically to clean, dry skin. The aim was to evaluate hydration and skin parameter changes following this method of application.

Treatment:

Other: Topical Hyaluronic Acid

Moist Skin Application

Experimental group

Description:

Participants in this group applied hyaluronic acid topically to pre-moistened skin. The goal was to assess whether applying the product to damp skin enhances its hydrating effect.

Treatment:

Other: Topical Hyaluronic Acid