Comparison of Skin Substitutes Used in Burn Care (Quad)

The University of Texas System (UT)

Status: Terminated

Conditions: Burns

Treatments: Procedure: Integra; Procedure: Homograft; Procedure: AlloDerm; Procedure: Autograft

Study type: Interventional

Funder types: Other

Identifiers

NCT00676013

97-286

Details and patient eligibility

About

The purpose of this study is to determine if using a DERMAL LAYER under skin grafts:

1. will reduce scar formation of skin grafts
2. will reduce burn wound contractures
3. will improve functional outcome of joints requiring grafts

Compare scarring outcome of Dermal products

Full description

Various skin substitutes are compared for healing, scar and functional and cosmetic outcomes.

Enrollment: 158 patients

Sex: All

Ages: Under 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Burn injury requiring grafting
• 0 years-90 years

Exclusion criteria

• Partial thickness burns only

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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158 participants in 1 patient group

Alloderm, Integra, Homograft, Autograft

Experimental group

Description:

Burn debridement and grafting using interventions of 1) AlloDerm, 2) Integra, 3) Homograft and 4) Autograft on four separate sites on each patient

Treatment:

Procedure: Autograft

Procedure: AlloDerm

Procedure: Homograft

Procedure: Integra