Comparison of Standard Opioid Prescription Versus Prescription Guided by Pharmacogenetic Analysis in Patients With Non-cancerous Chronic Pain. (AlgoPGx)

Centre Hospitalier Universitaire de Nīmes

Status

Withdrawn

Conditions

Non-cancerous Chronic Pain

Treatments

Other: Pharmacogenetic analysis allowing personalized opioid prescription

Other: Standard opioid prescription

Study type

Interventional

Funder types

Other

Identifiers

NCT03498014

NIMAO/2017-02/JCB-01

Details and patient eligibility

About

The investigators hypothesize that opioid prescription guided by patient pharmacogenetic profile will diminish opioid-associated undesirable effects by 50% and improve medication compliance.

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The patient must have given their free and informed consent and signed the consent form
The patient must be a member or beneficiary of a health insurance plan
The patient is at least 18 years old
The patient will be available for all visits
Patients suffer from non-cancerous chronic pain according to HAS criteria
Patient not having taking opioids in previous 2 months
Patient indicated for prescription of opioids (oxycodone, codeine or tramadol) or patient not responding to first line treatment

Exclusion criteria

The subject is participating in an category I interventional study, or is in a period of exclusion determined by a previous study
The subject refuses to sign the consent
It is impossible to give the subject informed information
The patient is under safeguard of justice or state guardianship
The patient is pregnant or breastfeeding
The patient is likely to procreate and does not use an effective method of contraception (contraceptive ring, surgical contraception, implant, patch, contraceptive pill, male and female condoms, IUD)
There is a contra-indication for opioid use
Patient with an addiction risk (score ≥ 8 on ORT scale).