Comparison of Standard Versus Low Bicarbonate Hemodialysis

Albert Einstein College of Medicine

Status and phase: Completed; Phase 1

Conditions: Chronic Kidney Disease; Metabolic Acidosis

Treatments: Other: Low bicarbonate dialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT01777178

2012-684

Details and patient eligibility

About

This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.

Enrollment: 10 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
• Age > 18 years

Exclusion criteria

• Use of oral alkali within the previous month
• Hospitalization within the previous month
• Inability to provide written informed consent
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Low bicarbonate dialysis

Experimental group

Treatment:

Other: Low bicarbonate dialysis