ClinicalTrials.Veeva

Menu

Comparison of Th1 Cytokine Levels Between Type 1 and Type 2 Diabetes

I

Istanbul Medeniyet University

Status

Completed

Conditions

Type 1 Diabetes
Type 2 Diabetes

Study type

Observational

Funder types

Other

Identifiers

NCT02860611
IstanbulMU

Details and patient eligibility

About

Recent reports show increased prevalence of obesity in patients with type 1 diabetes (T1DP)s while some studies stated that patients with type 2 diabetes (T2DPs) have islet cell auto-antibodies. These results raise the question of a common pathway in T1DM and T2DM via an association with T helper cells. In this study investigators aimed to investigate the difference between T helper 1 (Th1) cytokines levels in T1DPs, T2DPs and healthy subjects.

The study included 114 T1DPs on insulin treatment, 35 newly diagnosed T2DPs who had not used oral antidiabetics but insulin before and 31 healthy subjects (CG).

Serum interferon gamma (IFN-γ), interleukin-2 (IL-2) and tumor necrosis factor alpha (TNF-α) levels were measured using ELISA method. Serum levels of those cytokines in T1DPs were compared with those in T2DPs and controls.

Enrollment

180 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Being >18 years old
  • Giving consent to participate

Exclusion criteria

  • Acute and chronic inflammatory diseases
  • significant concomitant disease likely to interfere with glucose metabolism,
  • malignancies,
  • hemoglobinopathies,
  • In addition, glucose intolerance (fasting glucose level and that after glucose load) and HbA1C ≥ 5.7 % were also used exclusion criteria in the control group, group as American Diabetes Association (ADA) defined prediabetes as HbA1C between 5.7-6.4% (Standards of medical care in diabetes -2012. Diabetes care. 2012:35.)

Trial design

180 participants in 3 patient groups

Type 1 Diabetes
Description:
Patients with type 1 diabetes
Type 2 Diabetes
Description:
Patients with type 2 diabetes
Control
Description:
Healthy volunteers

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems