Comparison of the Analgesic Effect of Different Local Anesthetics in Interscalene Nerve Block for Shoulder Surgery

Antwerp University Hospital (UZA)

Status and phase: Completed; Phase 4

Conditions: Other Peripheral Nerve Disease

Treatments: Drug: Levobupivacaine 0.5%; Drug: Levobupivacaine 0.5% + epinephrin 1/200000; Drug: Ropivacaine 0.75%

Study type: Interventional

Funder types: Other

Identifiers

NCT02691442

EC 10/45/315

Details and patient eligibility

About

Several reports have compared the duration of action of levobupivacaine and ropivacaine as local anesthetic. The most widely used method for sensory function evaluation is though means of a pinprick test. The investigators want to use the novel method of Quantitative Sensory Testing to better evaluate the anesthetic activity. This method used hot and cold sensation to assess small nerve fiber function. The investigators will assess the duration of action of different drugs when used in an inter scalene nerve block in patients scheduled for shoulder surgery.

Full description

This study aims to compare the length of the analgesic effect of different local anesthesic solutions, used in an interscalene nerve block. This will be objectified by measuring the changes in small nerve functioning, using quantative sensory testing. Based on the results of a previous study, the investigators reduce the dose of the administered local anesthetic, expecting a similar length of action using these smaller doses.

Enrollment: 30 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesia class I or II
• Scheduled for shoulder surgery

Exclusion criteria

• Mental retardation
• Allergy for local anesthetics
• NSAID intolerance or contraindicated
• Diabetes mellitus
• Chronic use of pain killers

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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30 participants in 3 patient groups

Ropivacaine 0.75%

Active Comparator group

Description:

The investigators administer 5 milliliters of Ropivacaine 0.75% in the inter scalene space

Treatment:

Drug: Ropivacaine 0.75%

Levobupivacaine 0.5%

Active Comparator group

Description:

The investigators administer 5ml of Levobupivacaine 0.5% in the inter scalene space

Treatment:

Drug: Levobupivacaine 0.5%

Levobupivacaine 0.5% + epinephrin

Active Comparator group

Description:

The investigators administer 5ml of Levobupivacaine 0.5% + epinephrin 1/200000 in the inter scalene space

Treatment:

Drug: Levobupivacaine 0.5% + epinephrin 1/200000