Comparison of the Bilateral TAP Block Versus Curare in Muscle Relaxation of the Abdominal Wall During Laparoscopic Digestive Surgery: Prospective Randomized Study

Centre Hospitalier Universitaire, Amiens

Status and phase: Completed; Phase 4

Conditions: The Main of This Study is to Compare the Nerve Block of the Muscles of the Abdominal Wall Between the Bilateral TAP Block and Curare

Treatments: Drug: Curare; Drug: Transversus Abdominis Plane

Study type: Interventional

Funder types: Other

Identifiers

NCT01628952

PI2012_843_0007

2012-000673-23 (EudraCT Number)

Details and patient eligibility

About

This is a Biomedical Research, prospective, randomized, controlled single-blind mono centric, phase IV comparison trial of the bilateral TAP block versus curare in muscle relaxation of the abdominal wall during laparoscopic digestive surgery.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients older than 18 years and under 75 years
• Informed consent signed
• ASA I, II and III
• Patient affiliated to social security

Exclusion criteria

• ASA IV

  • BMI> 35 kg / m
  • Personal or family history of malignant hyperthermia
  • History of allergy or hypersensitivity to intravenous anesthetics (remifentanil), local anesthetics or muscle relaxants
  • Contraindications to sevoflurane: a history of malignant hyperthermia, history of liver disease after sevoflurane anesthesia, halogenated agents or hypersensitivity to any of these components.
  • Contraindications to succinylcholine: hyperkalemia, plasma cholinesterase deficiency nickname, para or tetraplegia more than 24 hours, burns over 24
  • Contraindications to cisatracurium: myasthenia
  • Neuromuscular diseases
  • Contraindications to local anesthetics: hypersensitivity to local anesthetics of the amide, intravenous regional anesthesia, porphyria, ventricular atrial conduction disturbances, epilepsy uncontrolled by treatment
  • Pregnancy and lactation
  • severe coagulation disorders
  • Inability to understand and give informed consent
  • Patient under guardianship, curatorship or protected
  • Indication of use of a hypnotic ketamine (BIS change)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

60 participants in 2 patient groups

TAP

Experimental group

Treatment:

Drug: Transversus Abdominis Plane

curare

Active Comparator group

Description:

Patients will be randomized into two parallel groups. One group will receive curare, another benefit of a bilateral TAP block

Treatment:

Drug: Curare