Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar

Near East University, Turkey

Status: Completed

Conditions: Swelling; Pain, Postoperative; Trismus

Treatments: Genetic: Advanced Platelet Rich Fibrin (A-PRF); Genetic: Leukocyte- and platelet-rich fibrin (L-PRF)

Study type: Interventional

Funder types: Other

Identifiers

NCT03672669

Near East University

Details and patient eligibility

About

In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus after mandibular third molar surgery. The study included a total of 27 patients with bilateral impacted mandibular third molar which surgically operated at different times. Patients were evaluated in two randomly separated groups. For the first group; A-PRF and for the second group; L-PRF was applied into the tooth socket. The outcomes variables were; pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed on the basis of; 1st, 2nd, 3rd and 7th days following the operation.

Enrollment: 27 patients

Sex: All

Ages: 18 to 26 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age≥18
• the presence of bilaterally symmetrically impacted mandibular third molar, which requires an extraction for prophylactic reasons
• absence of systemic diseases
• absence of chronic opioid taken;
• not being pregnant
• not smoking and no alcohol usage
• the absence of allergy to penicillin or any other drugs used during standardized postoperative therapy.

Exclusion criteria

• tooth needed to be sectioning during the operation
• operation time exceeding 30 minutes
• the cases with severe periodontal disease or acute pericoronitis,
• the cases using antibiotics for an existing infection
• the cases not capable of following postoperative instructions

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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27 participants in 2 patient groups

Advanced Platelet Rich Fibrin (A-PRF)

Active Comparator group

Description:

A-PRF was applied into the tooth socket after mandibular third molar surgery.

Treatment:

Genetic: Advanced Platelet Rich Fibrin (A-PRF)

Leukocyte- and platelet-rich fibrin (L-PRF)

Active Comparator group

Description:

L-PRF was applied into the tooth socket after mandibular third molar surgery.

Treatment:

Genetic: Leukocyte- and platelet-rich fibrin (L-PRF)