COMPARISON OF THE EFFECT OF DISTAL ADDUCTOR CANAL BLOCK COMBINED WITH GENICULAR NERVE BLOCK OR PERIARTICULAR INJECTION ON POSTOPERATIVE QOR-15 IN TOTAL KNEE ARTHROPLASTIES

Bezmialem Vakif University

Status: Completed

Conditions: Postoperative Pain; Recovery

Treatments: Procedure: Addukctor canal block; Procedure: periarticular injection; Procedure: genicular nerve block; Procedure: Spinal Anesthesia with Bupivacaine and Morphine

Study type: Interventional

Funder types: Other

Identifiers

NCT07077720

29.01.2025-E.180706

Details and patient eligibility

About

Objective: This study compares the effects of genicular nerve block (GNB) and periarticular injection (PAI), added to distal adductor canal block (ACB), on postoperative recovery quality (QoR-15), morphine use, and pain scores after total knee arthroplasty (TKA).

Methods: Sixty patients received spinal anesthesia and distal ACB, then were randomized to GNB (Group G, n=30) or PAI (Group P, n=30). QoR-15, morphine consumption, VAS pain scores, nausea/vomiting, and side effects were evaluated.

Full description

Objective: Total knee arthroplasty (TKA) is a common surgical procedure for knee pathologies of various etiologies, where postoperative pain management is critical for early mobilization and rehabilitation. Different blockade techniques targeting the femoral, obturator, and sciatic nerves, which provide sensory innervation to the knee, are evaluated in terms of analgesic efficacy and preservation of motor function. The adductor canal block (ACB) targets the saphenous nerve without affecting motor function, whereas periarticular injection (PAI) and genicular nerve block (GNB) provide more comprehensive analgesia by blocking other branches of the femoral nerve as well as the obturator and sciatic nerves. This study aims to compare the effects of GNB and PAI, applied in addition to distal ACB, on postoperative recovery quality measured by the Quality of Recovery-15 (QoR-15) score, morphine consumption, and pain scores in patients undergoing TKA.

Materials and Methods: This single-center, randomized, prospective study included patients over 18 years of age with ASA physical status I-III who were scheduled for total knee arthroplasty under spinal anesthesia. All patients received spinal anesthesia with 15 mg isobaric bupivacaine combined with 100 mcg intrathecal morphine. Additionally, all patients underwent ultrasound-guided distal adductor canal block. Patients were randomized into Group G (n=30) and Group P (n=30). Group G received preoperative genicular nerve block (5+5+5 ml of 0.25% bupivacaine), whereas Group P received intraoperative periarticular injection administered by the surgical team, consisting of 8 mg morphine, 40 mg methylprednisolone, 0.3 mg adrenaline, 750 mg cefazolin and 110 mg bupivacaine. The primary outcome measure was the quality of recovery evaluated by the Quality of Recovery-15 (QoR-15) questionnaire at 24 hours postoperatively. Secondary outcomes included morphine consumption at 2., 6., 12. and 24 hours postoperatively, resting and movement Visual Analog Scale (VAS) pain scores, postoperative nausea and vomiting (PONV) scores, and the incidence of adverse effects such as respiratory depression, urinary retention, and pruritus.

Enrollment: 60 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients scheduled for knee arthroplasty
• Patients classified as ASA I, II, or III
• Patients aged 18 years and older

Exclusion criteria

• Patients with a known allergy to any of the drugs used in the study
• Presence of infection near the puncture site
• History or presence of neurological disorders (e.g., transient ischemic attack, syncope, dementia, etc.)
• Known coagulation disorders
• History of alcohol or substance abuse
• Impaired consciousness
• Chronic opioid use equal to or exceeding 60 mg of oral morphine equivalents per day
• Pre-existing neuropathic pain
• Hepatic failure, renal failure, or cardiac insufficiency
• Uncontrolled diabetes mellitus
• Pregnant or breastfeeding women
• Refusal or inability to provide written informed consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

Grup G

Active Comparator group

Description:

Genicular nerve block

Treatment:

Procedure: Spinal Anesthesia with Bupivacaine and Morphine

Procedure: genicular nerve block

Procedure: Addukctor canal block

Grup P

Active Comparator group

Description:

Periarticular injecrion

Treatment:

Procedure: Spinal Anesthesia with Bupivacaine and Morphine

Procedure: periarticular injection

Procedure: Addukctor canal block