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Comparison of the Effect of Magnesium Sulfate and Dexamethasone on Postoperative Sore Throat After Spinal Surgery in Prone Position With Tracheal Intubation: a Double-blind, Randomized, Noninferiority Clinical Trial

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Yonsei University

Status

Completed

Conditions

Post Operative Sore Throat

Treatments

Drug: Magnesium Sulfate
Drug: dexamethasone

Study type

Interventional

Funder types

Other

Identifiers

NCT01923831
4-2013-0385

Details and patient eligibility

About

The purpose of this study is to compare the effect of magnesium sulfate and dexamethasone on postoperative sore throat after spinal surgery in prone position with tracheal intubation.

Enrollment

146 patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ASA I-II patients aged between 20 and 65 year undergoing 1 or 2 level posterior spinal fusion in prone position with tracheal intubation

Exclusion criteria

  • preexisting hoarseness or sore throat, upper respiratory tract infection
  • steroid therapy or immunocompromised patients
  • chronic treatment with calcium channel blocker or magnesium
  • allergy to magnesium sulphate
  • Cormack-Lehane grade 3,4 or patients who are expected to difficult intubation
  • fail to tracheal intubation at first trial
  • reduced kidney function
  • Diabetes mellitus

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

146 participants in 2 patient groups

Magnesium group
Experimental group
Treatment:
Drug: Magnesium Sulfate
Dexamethasone group
Active Comparator group
Treatment:
Drug: dexamethasone

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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