Comparison of the Effect of Magnesium Sulfate and Dexamethasone on Postoperative Sore Throat After Spinal Surgery in Prone Position With Tracheal Intubation: a Double-blind, Randomized, Noninferiority Clinical Trial

Yonsei University

Status: Completed

Conditions: Post Operative Sore Throat

Treatments: Drug: Magnesium Sulfate; Drug: dexamethasone

Study type: Interventional

Funder types: Other

Identifiers

NCT01923831

4-2013-0385

Details and patient eligibility

About

The purpose of this study is to compare the effect of magnesium sulfate and dexamethasone on postoperative sore throat after spinal surgery in prone position with tracheal intubation.

Enrollment: 146 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients aged between 20 and 65 year undergoing 1 or 2 level posterior spinal fusion in prone position with tracheal intubation

Exclusion criteria

• preexisting hoarseness or sore throat, upper respiratory tract infection
• steroid therapy or immunocompromised patients
• chronic treatment with calcium channel blocker or magnesium
• allergy to magnesium sulphate
• Cormack-Lehane grade 3,4 or patients who are expected to difficult intubation
• fail to tracheal intubation at first trial
• reduced kidney function
• Diabetes mellitus

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

146 participants in 2 patient groups

Magnesium group

Experimental group

Treatment:

Drug: Magnesium Sulfate

Dexamethasone group

Active Comparator group

Treatment:

Drug: dexamethasone