Comparison of the Effect of Online Physical Exercise and Computerized Cognitive Stimulation in Patients With Alzheimer's Disease

Yeditepe University

Status: Completed

Conditions: Alzheimer Disease; Telerehabilitation; Covid-19 Pandemic; Online Physical Exercise; Computerized Cognitive Stimulation

Treatments: Other: Physical exercise; Other: Physical exercise and computerized cognitive training

Study type: Interventional

Funder types: Other

Identifiers

NCT04842734

25.03.2021/37

Details and patient eligibility

About

Our aim has been determined to investigate the effect of physical exercise alone and in combination with cognitive exercise, on cognitive, physical function and quality of life in individuals with Alzheimer's Disease during the Covid-19 pandemic period.

Enrollment: 60 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 65 years and older
• Diagnosed with AD according to DSM-IV diagnostic criteria by a neurologist,
• MOCA ≥ 13
• Clinical Dementia Rating Scale < 2
• Having sufficient wireless support or telephone connection where the person lives
• Who gave consent to participate in the study
• No history of any neurological or orthopedic injury that could prevent participation in the study and affect functional mobility.

Exclusion criteria

• Geriatric Depression Scale score > 11
• Various mobility restrictions, musculoskeletal disorders, (wheelchair use, etc.)
• Clinically significant aphasia (must be able to understand the therapist's commands)
• Significant visual or sensory impairment
• MoCA < 13
• Having a severe musculoskeletal disorder
• Having paralysis
• Impaired balance
• The presence of severe lung and heart disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 3 patient groups

Physical exercise and computerized cognitive stimulation

Experimental group

Description:

Supervised Physical Exercise Program (SPEP) sessions will be performed simultaneously online together with the physiotherapist and the patient. Participants will be able to do the exercises together with their caregivers if needed. The Computerized Cognitive Stimulation Program (CCSP) (Beynex) will be planned for 12 weeks, 5 days a week, approximately 10 minutes, for a total of 40 sessions. Fisrtly, the use of CCSP will be demonstrated to the patients. Then, it will be given as home program. While the patients play the games in CCSP via their smartphones, their caregivers will be informed in detail about accompanying the patients if they need it. The follow-up of cognitive stimulation will be made with the person accompanying the patient over the phone. Individuals will be evaluated by a physiotherapist who will perform the assessment at pre-treatment, post-treatment (12th week) and follow-up period (24th week).

Treatment:

Other: Physical exercise and computerized cognitive training

physical exercise

Experimental group

Description:

SPEP sessions will be demonstrated to individuals by a 6-year-experienced physiotherapist via videoconference (Zoom Inc.) and the exercises will be performed simultaneously online together with the physiotherapist and the patient. Participants will be able to do the exercises together with their caregivers if needed. Individuals will be evaluated by a physiotherapist who will perform the assessment at pre-treatment, post-treatment (12th week) and follow-up period (24th week).

Treatment:

Other: Physical exercise

control

No Intervention group

Description:

The individuals included in this group will be informed that they should continue their normal daily life activities. Individuals will be evaluated by a physiotherapist who will perform the assessment at pre-treatment, post-treatment (12th week) and follow-up period (24th week).