Comparison of the Effect of Total Intravenous Anesthesia and Inhalation Anesthesia on Cancer Cell Cytotoxicity, Micrometastasis and Recurrence of Tumor in Patients Undergoing Breast Tumor Resection

Yonsei University

Status: Terminated

Conditions: Breast Cancer

Treatments: Procedure: inhalation anesthesia; Drug: sevoflurane-remifentanil; Procedure: intravenous anesthesia; Drug: propofol-remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT02089178

4-2013-0937

Details and patient eligibility

About

The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.

Enrollment: 48 patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
• breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies
• surgery performed by the same surgical team

Exclusion criteria

• ASA physical status Ⅳ
• hepatic and renal impairment
• diabetes or other endocrine disorders
• body mass index > 35 kg/m2
• immune disorders or immunosuppressive therapy
• steroid treatment in the last 6 months
• inflammation

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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48 participants in 2 patient groups

intravenous

Experimental group

Description:

the total intravenous anesthesia group

Treatment:

Procedure: intravenous anesthesia

Drug: propofol-remifentanil

inhalation

Active Comparator group

Description:

the inhalation anesthesia group

Treatment:

Procedure: inhalation anesthesia

Drug: sevoflurane-remifentanil