Comparison of the Effectiveness of Nerve Hydrodissection With Saline Injection of 5% Dextrose in Carpal Tunnel Syndrome.

Antalya Training and Research Hospital

Status: Active, not recruiting

Conditions: Conditions

Treatments: Drug: Nerve Hydrodissection with 5% Dextrose

Study type: Interventional

Funder types: Other

Identifiers

NCT07524933

2026528

Details and patient eligibility

About

Comparison of the effectiveness of nerve hydrodissection with saline injection of 5% dextrose in carpal tunnel syndrome.

Full description

Evaluation of pain, hand function, electrophysiological and ultrasonographic effects when comparing 5% dextrose saline injection via nerve hydrodissection under ultrasound guidance in mild to moderate carpal tunnel syndrome.

Enrollment: 96 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged 18-80 years
• Clinical and electrophysiological diagnosis of mild to moderate carpal tunnel syndrome
• Symptom duration of at least 3 months
• Both male and female participants
• Patients who have not responded adequately to conservative treatment
• Patients who do not wish to undergo surgical treatment
• Ability to provide informed consent

Exclusion criteria

• Severe or very severe carpal tunnel syndrome based on EMG findings
• Previous injection therapy for carpal tunnel syndrome
• Prior wrist or carpal tunnel surgery
• Polyneuropathy or other peripheral neuropathies
• Cervical radiculopathy or proximal median nerve entrapment
• Brachial plexopathy or thoracic outlet syndrome
• Pregnancy
• Malignancy
• Local or systemic infection
• Cognitive impairment affecting cooperation
• Systemic diseases affecting the median nerve (e.g., uncontrolled diabetes mellitus, thyroid disorders)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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96 participants in 3 patient groups

5% dextrose group

Active Comparator group

Description:

Ultrasound-guided median nerve hydrodissection with 5% dextrose

Treatment:

Drug: Nerve Hydrodissection with 5% Dextrose

Saline group

Sham Comparator group

Description:

Sham ultrasound-guided perineural injection with normal saline

Treatment:

Drug: Nerve Hydrodissection with 5% Dextrose

Splint group

Sham Comparator group

Description:

Patients use only a wrist splint without injection therapy

Treatment:

Drug: Nerve Hydrodissection with 5% Dextrose