Comparison of the Effectiveness of Oral Lactase Enzyme and Lactose Free Formula

Muhammad Aamir Latif

Status

Completed

Conditions

Secondary Lactose Intolerance

Treatments

Dietary Supplement: Lactase enzyme

Dietary Supplement: Lactose-free formula feed

Study type

Interventional

Funder types

Other

Identifiers

NCT06827405

ZUHKARACHI

Details and patient eligibility

About

This study aimed to fill the gaps by comparing the effectiveness of oral lactase enzyme and lactose free formula in the management of secondary lactose intolerance in persistent and severe persistent diarrhea.

Full description

Although it is well understood that oral lactase enzyme can play a pivotal role in hastening recovery due to secondary lactose intolerance in persistent diarrhea, there is limited local data available in this regard. If exogenous oral lactase enzyme is found to be more effective, it would help children receive uninterrupted milk and milk-based diet during the diarrheal episode, as the former would aid digestion and absorption of lactose, thus providing the necessary nutrients especially (calcium) and vitamins so vital in this period of rapid growth.

Enrollment

50 patients

Sex

All

Ages

6 to 24 months old

Volunteers

No Healthy Volunteers

Inclusion criteria

Both genders
Aged 6-24 months
Presented with persistent or severe persistent diarrhea due to secondary lactose intolerance
Patients on formula or mixed feeding, or formula/cow/buffalo milk

Exclusion criteria

Severe acute malnutrition
Hemodynamic instability (shock)
Those on oral antibiotics or on excessive juices
With conditions of malabsorptive states (celiac disease, protein losing enteropathy, or irritable bowel syndrome)