Comparison of the Effects of a 12-Week Consumption of Two Carbonated Beverages on Insulin Sensitivity (SEDULC)

Institute For European Expertise in Physiology

Status

Completed

Conditions

Glucose Homeostasis

Treatments

Dietary Supplement: Drink with sweeteners

Dietary Supplement: Drink without sweeteners

Study type

Interventional

Funder types

Industry

Identifiers

NCT02031497

120901-10 (Other Identifier)

2012EL0905SEDULC

Details and patient eligibility

About

The purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.

Full description

Sweeteners are natural or synthetic sugar substitutes which provide a sweetness taste to drink and food with few or no additional calories. Sweeteners are widely used in commercialized beverages. Despite some debate, no significant toxicity was demonstrated at a reasonable level of consumption (less than 20 cans per day). However little data is available on the metabolic effects of a regular consumption of beverages containing sweeteners. The objective of the study is to evaluate the effect of a regular consumption (twice a day for 12 weeks) of a carbonated drink with sweeteners, in a normal diet, compared with unsweetened sparkling water on insulin sensitivity in healthy normoweight and overweight subjects.

Enrollment

60 patients

Sex

All

Ages

18 to 50 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Healthy male or female
Subject taking at least three main meals (breakfast, lunch, dinner)
Subject able to understand and sign an informed consent
Subject drinking and enjoying soft drinks
Subject appreciating sweeteners taste
19 kg/m² < BMI< 30 kg/m²

Exclusion criteria

Any severe or acute illness that may influence the results of the study or may be life-threatening
Pregnant or breastfeeding subject
Past or present metabolic or digestive diseases, with the exception of a possible appendectomy
Diabetes or severe acute illness that may alter blood sugar
Treatment that may interfere with glucose homeostasis
Past or present kidney disease (renal failure, ... )
Local or systemic medication that may change water status, metabolism and feeding behavior
Antiplatelet treatment
Alcohol consumption ≥ 3-4 glasses / day ( ≥ 21 drinks / week )
Sustained physical exercise (more than 4 hours per week)
Subject adding sweeteners (tablets or powder) in their diet
Subject drinking more than two cans of drinks with sweeteners / day
Subject dieting to lose weight
Subject unable or unwilling to consume 2 liters of fluid / day