Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

Istanbul University

Status: Unknown

Conditions: Pituitary Adenoma

Treatments: Drug: Sevoflurane; Drug: Propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02709863

83045809/604.01/02 (Other Identifier)

Details and patient eligibility

About

This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Full description

Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) score I-II patients

Exclusion criteria

• Significant cardiopulmonary disease,
• Diagnosed obstructive or restrictive pulmonary disease,
• Patients with chest wall deformities, liver or kidney failure,
• Postoperative lack of cooperation

Trial design

90 participants in 3 patient groups

Sevoflurane

Active Comparator group

Description:

1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation

Treatment:

Drug: Sevoflurane

Desflurane

Active Comparator group

Description:

1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation

Treatment:

Drug: Desflurane

Propofol

Active Comparator group

Description:

6-10 mg/kg/h, iv infusion, during operation

Treatment:

Drug: Propofol