Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests

I

Istanbul University

Status

Unknown

Conditions

Pituitary Adenoma

Treatments

Drug: Sevoflurane
Drug: Propofol
Drug: Desflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02709863
83045809/604.01/02 (Other Identifier)

Details and patient eligibility

About

This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland. Participants will be divided into three equal groups. The first group will receive sevoflurane, second grup will receive desflurane and third grup will receive total intravenous anaesthesia. Investigators are also going to evaluate blood gas analysis.

Full description

Investigators are going to evaluate forced expiratory volume in 1st Second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, partial pressure of arterial oxygen (PaO2), partial pressure of arterial carbon dioxide (PaCO2), potential of hydrogen (pH), arterial oxygen saturation (SaO2), base excess (BE), bicarbonate (HCO3) and partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) ratio to compare the effects of drugs.

Enrollment

90 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

American Society of Anesthesiologists (ASA) score I-II patients

Exclusion criteria

  • Significant cardiopulmonary disease,
  • Diagnosed obstructive or restrictive pulmonary disease,
  • Patients with chest wall deformities, liver or kidney failure,
  • Postoperative lack of cooperation

Trial design

90 participants in 3 patient groups

Sevoflurane
Active Comparator group
Description:
1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation
Treatment:
Drug: Sevoflurane
Desflurane
Active Comparator group
Description:
1-1.5 minimum alveolar concentration (MAC), inhalation route, during operation
Treatment:
Drug: Desflurane
Propofol
Active Comparator group
Description:
6-10 mg/kg/h, iv infusion, during operation
Treatment:
Drug: Propofol

Trial contacts and locations

1

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Central trial contact

Abdulvahap Oguz, MD

Data sourced from clinicaltrials.gov

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