Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Izmir Democracy University

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Other: prp injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06408922

prpknee2023

Details and patient eligibility

About

80 patients diagnosed with knee osteoarthritis were randomized into two groups: patients in Group 1 received a single intraarticular injection of PRP whereas those in group 2 were administered three intraarticular injections of PRP within an interval of 2 weeks between each application. Patients were evaluated before the treatment and at the 6 month after the treatment with a Visual Analog Scale (VAS) and The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index.

Enrollment: 80 patients

Sex: All

Ages: 35 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ages of 35 and 80
• Kellgren-Lawrence grade of 2, 3, or 4

Exclusion criteria

• rheumatic diseases, coagulopathies, severe cardiovascular diseases, local infections, malignancies, immunodeficiency, schizophrenia, mental retardation, anticoagulant therapy, a hemoglobin concentration of 11 g/dL and platelets of 150,000/L, a history of severe trauma, or a history of hyaluronic acid or corticosteroid injection within the previous 6 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups

Single prp injection

Active Comparator group

Description:

single intraarticular prp injection

Treatment:

Other: prp injection

triple prp injection

Active Comparator group

Description:

triple intraarticular prp injection

Treatment:

Other: prp injection