Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Craniectomy; Hospital Costs; Sugammadex; Recovery After Neuromuscular Block; Extubation

Study type: Observational

Funder types: Other

Identifiers

NCT06987357

KAEK/2021.04.116

Details and patient eligibility

About

The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients undergoing cranial surgery under general anesthesia, on early extubation in the operating room, intensive care unit admission and length of stay, length of hospital stay, and hospital costs.

Enrollment: 112 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients from the American Society of Anesthesiology (ASA) I-II-III group,
• over the age of 18,
• who underwent elective surgery,
• underwent general anesthesia with sevoflurane anesthesia from volatile anesthetics,
• used rocuronium as a neuromuscular blocking agent

Exclusion criteria

• Patients aged 18 and under,
• ASA IV and above,
• who underwent surgery under emergency conditions,
• who have incomplete follow-up form records and electronic media data,
• who were taken to the intensive care unit without neuromuscular blockade antagonism due to long surgery,
• who were treated with a neuromuscular blocking agent other than rocuronium,
• who were treated with a volatile anesthetic other than sevoflurane or with total intravenous anesthesia.

Trial design

112 participants in 2 patient groups

Group Neostigmine

Group Sugammadex