Comparison of the Effects of TIVA vs VIMA on Content of GSK-3beta in Leucocytes in On-pump Patients

Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Status and phase: Terminated; Phase 4

Conditions: Glycogen Synthase Kinase 3

Treatments: Drug: Propofol; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02686710

GSK-TV-L

Details and patient eligibility

About

Assessment of GSK-3beta contents in leukocytes in on-pump cardiosurgical patients receiving either volatile or intravenous anesthesia

Enrollment: 10 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

elective on-pump CABG

Exclusion criteria

re-operation

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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10 participants in 3 patient groups

VIMA

Active Comparator group

Description:

Patiens receiving volatile induction and maitenance of anesthesia

Treatment:

Drug: Sevoflurane

TIVA

Active Comparator group

Description:

Patiens receiving total intravenous anesthesia based on propofol

Treatment:

Drug: Propofol

Combi

Active Comparator group

Description:

Patiens receiving total intravenous induction and volatile anesthesia

Treatment:

Drug: Sevoflurane

Drug: Propofol