Comparison of the Effects of Two Different Local Anesthetics Used in Spinal Anesthesia

Ankara Ataturk Sanatorium Training and Research Hospital

Status: Completed

Conditions: Local Anaesthesia

Treatments: Drug: Chirocaine; Drug: Bupivacaine

Study type: Observational

Funder types: Other

Identifiers

NCT06763510

26247029-514-04-01

Details and patient eligibility

About

Objective: This study aimed to compare the effects of two different local anesthetics with different baricity used in spinal anesthesia on thermoregulation.

Materials and Methods: The study was conducted on forty full-term pregnant women scheduled for elective cesarean sections under spinal anesthesia. At an operating room temperature of twenty-four degrees Celsius, peripheral body temperature was measured using temperature probes attached to the lower medial parts of the same side's lower and upper extremities, and central body temperature was measured with a tympanic thermometer. Isobaric levobupivacaine and hyperbaric bupivacaine were used in spinal anesthesia applications. After spinal anesthesia, tympanic temperature, arm and leg temperatures, mean arterial pressure, heart rate, and oxygen saturation were measured and recorded at baseline, the first, third, and fifth minutes, and every five minutes thereafter until the end of surgery.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Term pregnant with elective cesarean section planned under spinal anesthesia
• ASA I-II
• 18-40 years old

Exclusion criteria

• patients in whom spinal anesthesia is contraindicated,
• patients with neuromuscular disease,
• alcohol and substance abusers,
• patients with a body mass index (BMI) <18.5 kg/m² or >35 kg/m²,
• those taking medications that may affect thermoregulation such as vasodilators,
• patients with thyroid disease,
• patients with fever and infection,
• patients with known allergies to study drugs.

Trial design

40 participants in 2 patient groups

Isobaric levobupivacaine

Treatment:

Drug: Chirocaine

Hyperbaric bupivacaine

Treatment:

Drug: Bupivacaine