Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)

Merck Sharp & Dohme (MSD)

Status and phase: Completed; Phase 3

Conditions: Glaucoma; Ocular Hypertension

Treatments: Drug: MK0507A, dorzolamide hydrochloride (+) timolol maleate; Drug: Duration of Treatment: Part 1) 6 wk timolol maleate run in; Drug: Comparator: timolol maleate; Drug: Part 2) 6 wk washout pd Part 3) two 8 wk active tx pds

Study type: Interventional

Funder types: Industry

Identifiers

NCT00108017

0507A-137

2005_021

Details and patient eligibility

About

This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.

Enrollment: 330 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with glaucoma or ocular hypertension

Exclusion criteria

• Other eye conditions
• Poor vision
• Recent eye surgery
• Use of contact lenses
• Nursing or pregnant women
• Use of some other selected medications
• Drug or alcohol abuse
• Asthma
• Slow heart beat
• Allergy or previous reaction to study drugs

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind