Comparison of the Effects of Weight Changes on Serum Adipokines in Patients Diagnosed With Anorexia Nervosa and Morbid Obesity

Istanbul University

Status: Completed

Conditions: Bariatric Surgery; Anorexia Nervosa; Weight Change, Body

Treatments: Procedure: Bariatric surgery-RYGB; Behavioral: Dietary intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT04663919

246164

Details and patient eligibility

About

In this study, when patients diagnosed with AN started treatment and their weight increased by 10%; On the other hand, it was aimed to compare the changes in serum adipokine levels observed in morbidly obese patients before bariatric surgery and when they lost 10% of their post-op weight with both anthropometric measurements, biochemical parameters, and values of healthy volunteers.

Full description

The most characteristic feature of obesity is the increase in adipose tissue. On the contrary, in anorexia nervosa, there is a decrease in adipose tissue enough to impair neuroendocrine functions. Adipose tissue is formed by loosely binding lipid-filled cells called adipocytes and is now considered an important part of energy metabolism. Adipokines it secretes play a role in many physiological processes of the body such as nutrition, appetite, energy balance, insulin, and glucose metabolism, lipid metabolism, regulation of blood pressure, vascular remodeling, coagulation, and inflammation.

Therefore, changes in the amount of body fat in these two patient groups, which are at the two ends of the spectrum, affect both the biochemical parameters and physiological functions of the patients in different ways. It is expected that both adipokine levels and biochemical parameters will approach the values of healthy subjects with a decrease in adipose tissue of clinically morbidly obese patients and an increase in adipose tissue of patients with AN. However, in some studies comparing the parameters of patients with constitutionally weak patients and patients with AN, results contrary to expectations were obtained. In this study, we compared the extent to which weight changes changed adipokines and correlated with biochemical parameters based on healthy and normal-weight volunteers.

Enrollment: 55 patients

Sex: All

Ages: 13 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• for Anorexia Nervosa group:

  • Have been diagnosed with anorexia nervosa
  • BMI <18 kg/m2
  • Good general health
  • Volunteering to participate in the study

• for Morbidly Obese group:

  • Who was diagnosed with morbid obesity and planned to undergo RYGB operation
  • BMI> 40 kg/m2
  • Volunteering to participate in the study

• for Healthy Volunteers:

  • Good general health
  • BMI >20 and <30 kg/m2
  • Volunteering to participate in the study

Exclusion criteria

• <13 and> 60 years old
• to had type 2 diabetes, hypertension, liver and kidney failure, cancer, or a chronic disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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55 participants in 3 patient groups

Anorexia Nervosa

Active Comparator group

Description:

Patients diagnosed with Anorexia Nervosa, having a BMI of \<18, being followed up and treated in the Psychiatry Eating Disorders Polyclinic and endocrinology outpatient clinics, and who have approximately 10% weight gain during the treatment process

Treatment:

Behavioral: Dietary intervention

Morbidly Obese

Active Comparator group

Description:

Patients with a BMI\> 40 diagnosed with Morbid Obesity and who lost approximately 10% of their weight by performing obesity surgery (gastric bypass or sleeve gastrectomy)

Treatment:

Procedure: Bariatric surgery-RYGB

Healthy Volunteer

No Intervention group

Description:

Volunteers with normal BMI and without any additional chronic disease