Comparison of the Efficacy and Safety of Ivermectin to Permethrin

University Ghent

Status and phase: Completed; Phase 2

Conditions: Scabies

Treatments: Drug: Administration of ivermectin or permethrin

Study type: Interventional

Funder types: Other

Identifiers

NCT00262418

2004/212

Details and patient eligibility

About

Comparison of the efficacy and safety of a single administration of ivermectin to a single administration of permethrin for the treatment of scabies

Full description

Administration of ivermectin or permethrin on day0 Clinical examination and pictures on day0, day14 and day28 Blood sample on day0 VAS for pruritus, DLQI and SF-36 on day0, day14 and day28

Enrollment: 160 patients

Sex: All

Ages: 5+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

At least one of the following inclusion criteria:

• Scabies tunnels
• Positive microscopic examination (acarids, faeces or ova)

At least two of the three following inclusion criteria:

• Non-specific injuries with a typical distribution pattern
• Serious itching which increases during the night
• Family or contacts with similar complaints

Exclusion criteria

• Treatment for scabies < 4 weeks ago
• Treatment with corticoids < 1 week ago
• Pregnancy
• Breast-feeding
• HIV
• Serious immunodepressive patients
• Sensitivity or allergy to one of the components of the study medication
• Damage of the central nerve system

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind