Comparison of the Efficacy Between Transurethral Coagulation and Transurethral Resection of Ulcer in Bladder Pain Syndrome Patients

Samsung Medical Center

Status: Completed

Conditions: Bladder Pain Syndrome

Treatments: Procedure: Transurethral Coagulation (TUC); Procedure: Transurethral Resection(TUR)

Study type: Observational

Funder types: Other

Identifiers

NCT01963988

2013-05-127

ksleedr (Registry Identifier)

Details and patient eligibility

About

On the EAU (European Association of Urology) guidelines, the ulcer type bladder pain syndrome (BPS) should be treated with transurethral resection (TUR) or coagulation (TUC) of ulcer.

But, Up to date, there was no study to compare the therapeutic efficacy of TUR with TUC in ulcer type BPS patients.

We assume TUR have a more therapeutic effect than TUC.

Enrollment: 126 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male and female aged 18 yrs or greater
2. Patients diagnosed with BPS(Bladder Pain Syndrome)
3. Symptom persisted more than 6 months
4. Pain VAS ≥4
5. O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) scores 12 or greater with pain and nocturia domain scores > 2.
6. Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF) >13
7. No history of cystoscopy within 2yrs.

Exclusion criteria

1. History of augmentation cystoplasty or previous transurethral coagulation/resection due to BPS
2. Child-bearing potential, pregnant or nursing women.
3. Mean voided volume lesser than 40ml or over than 400ml.
4. Hematuria exceeds 1+ in the urinary dipstick (dipstick) examination.
5. Urinary tract infection during run-in periods.
6. Genitourinary tuberculosis or bladder,urethral and prostate cancer
7. Recurrent urinary tract infection
8. History of hysterectomy,mid-urethral sling,pelvic organ prolapse repair,vaginal delivery or Cesarean section,prostate operation or treatment etc within 6months.
9. Neurologic disease history of cerebral infarction,multiple sclerosis or parkinsonism etc.

Trial design

126 participants in 2 patient groups

Transurethral Coagulation (TUC)

Description:

This cohort patients will be managed with Transurethral Coagulation (TUC) of IC ulcer lesion

Treatment:

Procedure: Transurethral Coagulation (TUC)

Transurethral Resection(TUR)

Description:

This cohort patients will be managed with transurethral resection(TUR) of IC ulcer lesion

Treatment:

Procedure: Transurethral Resection(TUR)