Comparison of the Efficacy of Boric Acid Mouthwashes in Different Concentrations

Yuzuncu Yıl University

Status and phase: Active, not recruiting; Phase 4

Conditions: Impacted Third Molar Tooth

Treatments: Procedure: Chlorhexidine mouthwash with boric acid (2%); Procedure: Boric acid mouthwash (2%); Procedure: Chlorhexidine mouthwash with boric acid (0.1%); Procedure: Chlorhexidine mouthwash with boric acid (0.5%); Procedure: Chlorhexidine mouthwash with boric acid (2.5%); Procedure: Chlorhexidine mouthwash with boric acid (1.5%); Procedure: Chlorhexidine mouthwash with boric acid (1%); Drug: Chlorhexidine mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT04376268

01.08.2018/07

Details and patient eligibility

About

Surgical removal of impacted third molars is one of the most frequent procedures carried out in the oral and maxillofacial surgery clinics. There are a varying range of postoperative complications including pain, edema and swelling. Antibiotics, analgesics and mouthwashes are usually prescribed for the treatment of these complications. Patients undergoing impacted third molar surgery are frequently prescribed chlorhexidine mouthwashes with/without benzydamine hydrochloride. However, there has been a search for alternatives with anti-inflammatory, antibacterial and analgesic properties as part of the oral care routine following surgical removal of impacted third molars. Thus, this multicenter study was aimed to evaluate the effects of chlorhexidine mouthwashes with different boric acid concentrations (%0.1, %0.5, %1, %1.5, %2 and %2.5), and boric acid mouthwash on the postoperative complications and compared with chlorhexidine mouthwash after the removal of impacted wisdom teeth.

Enrollment: 80 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• absence of any systemic disease
• having impacted mandibular third molar teeth in a similar position
• absence of allergy to any of the drugs used in the study,
• absence of pregnancy/lactating state,
• no history of any medication use during at least 2 week before the operation.

Exclusion criteria

• not regularly coming to the controls,
• not using their medicines regularly
• using any additional medication that may affect the outcome of the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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80 participants in 8 patient groups

Chlorhexidine gluconate

Active Comparator group

Description:

Chlorhexidine is one of the most commonly used medications after tooth extraction. It exhibits a wide spectrum of antiseptic, bactericidal and bacteriostatic effects.

Treatment:

Drug: Chlorhexidine mouthwash

Chlorhexidine mouthwash with boric acid (0.1%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (0.1%)

Chlorhexidine mouthwash with boric acid (0.5%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (0.5%)

Chlorhexidine mouthwash with boric acid (1%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (1%)

Chlorhexidine mouthwash with boric acid (1.5%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (1.5%)

Chlorhexidine mouthwash with boric acid (2%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (2%)

Chlorhexidine mouthwash with boric acid (2.5%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Chlorhexidine mouthwash with boric acid (2.5%)

Boric acid mouthwash (2%)

Active Comparator group

Description:

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Treatment:

Procedure: Boric acid mouthwash (2%)