Comparison of the Efficacy of Clindamycin Phosphate 1% Gel Versus Once-daily Dapsone 5% Gel in the Treatment of Moderate Acne Vulgaris

Jinnah Postgraduate Medical Centre

Status and phase: Completed; Phase 2

Conditions: Acne Vulgaris

Treatments: Drug: Clindamycin and Dapsone gel for 03 months

Study type: Interventional

Funder types: Other

Identifiers

NCT05926869

NO.F.2-81/2022-GENL/250/JPMC

Details and patient eligibility

About

Acne vulgaris (AV) is a disease of the pilosebaceous unit that causes noninflammatory lesions (open and closed comedones), inflammatory lesions (papules, pustules, and nodules), and varying degrees of scarring. The key pathogenic processes includes alteration of follicular keratinization that leads to comedones; increased and altered sebum production under androgen control; follicular colonization by Propionibacterium acnes; . The role of topical antibiotics in treating acne is well established. Clindamycin is a topical antibiotic which has been widely used in treatment of acne for many decades. The extensive use of antibiotics in acne has lead to the development of resistance to antimicrobial therapy. Dapsone is known to have antibacterial as well as anti-inflammatory action which may help in reduction of acne.

Full description

Topical Dapsone 5% gel contains sulfone and has an advanced solvent micro particulate delivery system that enables penetration of stratum corneum . It is a new topical drug used in the treatment of Moderate Acne Vulgaris.

Enrollment: 100 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• moderate acne vulgaris
• either gender
• 20 to 50 yrs

Exclusion criteria

• systemic treatment taken
• pregnant or lactating women
• hematological abnormalities

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Group A Clindamycin gel

Experimental group

Treatment:

Drug: Clindamycin and Dapsone gel for 03 months

Group B Dapsone gel

Experimental group

Treatment:

Drug: Clindamycin and Dapsone gel for 03 months