Comparison of the Genotoxicity of Desflurane and Propofol

Muğla Sıtkı Koçman University

Status: Completed

Conditions: DNA Damage; Anesthesia

Treatments: Drug: Anesthetics, General Propofol Maintenance; Drug: Anesthetics, General Desflurane Maintenance

Study type: Interventional

Funder types: Other

Identifiers

NCT05185167

MSKU 05/III

Details and patient eligibility

About

The purpose of this study is to evaluate if the anesthetics propofol and desflurane can damage DNA according to comet essay in patients submitted to lumbar disc surgery.

Full description

It is expected that DNA damage information provide the possible genotoxic effects of inhalational and intravenous anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed patients.

Enrollment: 30 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Ability to understand and willingness to sign an informed consent form
2. Elective lumbar spinal surgery that will take at least 120 minutes,
3. American Society of Anesthesiologists (ASA) physical status I and II

Exclusion criteria

1. Patients with ASA physical status III or IV disease
2. Chronic systemic disease (diabetes mellitus,chronic pulmonary disorders, chronic kidney and liver disorders)
3. Smoking or alcohol consumption
4. Recently received radiation, chemotherapy
5. Malignancy
6. Patients who will receive blood transfusion during the operation
7. Users of antioxidant supplements
8. Patients who have received general anesthesia in the last three months
9. Patients with known occupational exposures (operating room personnel, chemical plant worker

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Double Blind

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30 participants in 2 patient groups

Desflurane Group

Experimental group

Description:

Desflurane 1,0 minimum alveolar concentration will be administered during anesthesia maintenance

Treatment:

Drug: Anesthetics, General Desflurane Maintenance

Propofol Group

Experimental group

Description:

Propofol 6 mg//kg/hour will be administered during anesthesia maintenance

Treatment:

Drug: Anesthetics, General Propofol Maintenance