Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.

Institute of Liver and Biliary Sciences, India

Status: Completed

Conditions: Healthy Blood Donor

Treatments: Diagnostic Test: Titres on conventional test tube method with different diluent

Study type: Observational

Funder types: Other

Identifiers

NCT07054372

ILBS-Titres-01

Details and patient eligibility

About

Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection. Although the conventional tube technique (CTT) remains the gold standard, its standardization is challenging, partly influenced by the choice of diluents. This study aimed to compare commonly used diluents in ABO antibody titration via CTT and analyze the resulting titre variations.

Enrollment: 200 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Blood Donor.

Exclusion criteria

• Samples from female donors, those with irregular antibodies and reactive to transfusion-transmissible infections on routine testing, were excluded.

Trial design

200 participants in 1 patient group

Healthy Blood Donor

Description:

Healthy Blood Donor

Treatment:

Diagnostic Test: Titres on conventional test tube method with different diluent