Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars

RANA AHMAD

Status and phase: Not yet enrolling; Phase 4

Conditions: Irreversible Pulpitis With Apical Periodontitis; Symptomatic Apical Periodontitis

Treatments: Drug: piroxicam 20mg; Drug: Group B: patients will be given prednisolone 20mg as premedication

Study type: Interventional

Funder types: Other

Identifiers

NCT07281807

TUF/IRB/28/2025

Details and patient eligibility

About

To compare the post operative mean pain scores by administering single-dose preoperative piroxicam and prednisolone in patients of irreversible pulpitis with symptomatic apical periodontitis.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy patient ranging between 18-40 years
• Having at least one premolar with diagnosis of symptomatic irreversible pulpitis according to history, examination and radiographs.
• Teeth having mature apex confirmed by periapical radiographs.

Exclusion criteria

• History of systemic disorders including HIV, Hepatitis

  • Pregnancy (As per Medical record/ Verbally)
  • Patient using medication such as analgesics or anti-inflammatory drugs
  • Patient allergic to lignocaine, piroxicam and prednisolone
  • Tooth not suitable for restoration
  • Periodontal probing depth ≥ 4mm
  • Retreatment cases
  • Patients having calcified canals assessed by radiographic findings

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Group A: piroxicam

Experimental group

Description:

Group A: patients will be given piroxicam 20mg as premedication

Treatment:

Drug: piroxicam 20mg

Group B: prednisolone

Active Comparator group

Description:

Group B: patients will be given prednisolone 20mg as premedication

Treatment:

Drug: Group B: patients will be given prednisolone 20mg as premedication