Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty

Guangzhou General Hospital of Guangzhou Military Command

Status and phase: Unknown; Phase 4

Conditions: Complications; Pain

Treatments: Procedure: Nerve Block; Drug: opioid; Procedure: Intravenous analgesic; Drug: ropivacaine; Procedure: Local analgesic

Study type: Interventional

Funder types: Other

Identifiers

NCT02094339

Unilateral Knee Replacement

Details and patient eligibility

About

Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular infiltration with local anesthetics. All of these treatments may lead to side effects such as nausea, headache, hypotension, urinary retention, partial motor block and infection of the knee. Therefore the investigators will compare three methods of postoperative analgesic after TKA by their efficiency and complication.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
2. Aged between 18 and 85 years
3. Undergoing elective total knee replacement

Exclusion criteria

1. Mental illness can not match
2. Nerve block, epidural anesthesia contraindicated
3. People who have Slow-type arrhythmias
4. History of chronic headaches and long-term use of analgesic drugs
5. People who were postoperative consciousness, language or hearing impaired

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

45 participants in 3 patient groups

Local analgesic

Experimental group

Description:

This group uses local analgesia infusion pump of 0.2% ropivacaine 360ml through periarticular infiltration for postoperative analgesia.

Treatment:

Drug: ropivacaine

Procedure: Local analgesic

Drug: ropivacaine

Nerve Block

Active Comparator group

Description:

People in this group will receive a postoperative pain management by continuous lumbar plexus block with 0.2% ropivacaine.

Treatment:

Drug: ropivacaine

Procedure: Nerve Block

Drug: ropivacaine

Intravenous analgesic

Active Comparator group

Description:

This group is treated with intravenous electronic analgesia pump infusion of flurbiprofen axetil 250mg,palonosetron 0.5mg,pentazocine 240mg.dezocine 30mg.

Treatment:

Procedure: Intravenous analgesic

Drug: opioid