Comparison of Three Technical Airway Clearance in Mechanical Ventilated Patients (ClearanceMV)

Hospital de Clinicas de Porto Alegre

Status: Completed

Conditions: Physical Disability; Mucociliary Clearance Defect

Treatments: Other: Vibrocompression (VB); Other: HMV+VB; Other: Hyperinflation (HMV)

Study type: Interventional

Funder types: Other

Identifiers

NCT02604082

11-0367

Details and patient eligibility

About

Randomized clinical trial, conducted in the Intensive Care Unit of the Hospital de Clinicas de Porto Alegre from october 2011 until november 2015 .

Full description

Objective: To compare the effectiveness of techniques: vibrocompression (G1), hyperinflation with mechanical ventilation (G2) vibrocompression + hyperinflation with mechanical ventilation (G3) in the amount of aspirated secretions, mechanical ventilator time, incidence of ventilator-associated pneumonia , reintubation tracheal and mortality in mechanical ventilator. Primary outcome: weight in grams of the aspirated secretions. Secondary outcome: hemodynamic and pulmonary parameters: heart rate, respiratory rate, mean arterial pressure, peripheral arterial oxygen saturation; peak inspiratory pressure, tidal volume; dynamic compliance ; mechanical ventilator time; reintubation tracheal; Incidence of ventilator-associated pneumonia and mortality in mechanical ventilator.

Enrollment: 93 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• In mechanical ventilation for a period of 24-72 h
• End-expiratory pressure (PEEP) lower 10 cm of water.
• Lower noradrenaline doses of 0.5mg / kg / minute for an average greater than or equal blood outstrips 60 mmHg.

Exclusion criteria

• Pneumothorax and hemothorax undrained
• Subcutaneous emphysema
• Osteoporosis
• Acute respiratory distress syndrome - (ARDS)
• Fractures of ribs
• Obese ( BMI greater than 35)
• Mechanical ventilator with higher peak pressures 40 cm of water.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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93 participants in 3 patient groups

Vibocompression (VB)

Active Comparator group

Description:

Grup 1 - Vibrocompression: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration

Treatment:

Other: Vibrocompression (VB)

Hyperinflation (HMV)

Active Comparator group

Description:

Grup 2 - Hyperinflation with Mechanical ventilator: Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the increase in inspiratory pressure ventilator .

Treatment:

Other: Hyperinflation (HMV)

HMV+VB

Experimental group

Description:

Grup 3 - Hyperinflation with mechanical ventilator and vibrocompression:Is a physical therapy technique, that aims to clear the airways of patients on mechanical ventilation. Through the thoracic compression during expiration and the increase in inspiratory pressure ventilator.

Treatment:

Other: HMV+VB