Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting

Incheon St.Mary's Hospital

Status: Completed

Conditions: Postoperative Nausea and Vomiting

Treatments: Drug: Total intravenous anesthesia; Drug: Total intravenous anesthesia plus palonosetron

Study type: Interventional

Funder types: Other

Identifiers

NCT01478165

OC11MISI0090

Details and patient eligibility

About

A total intravenous anesthesia (TIVA) is a useful anesthetic technique that reduces the incidence of postoperative nausea and vomiting (PONV).

Investigator hypothesized the incidence of PONV can be further reduced when palonosetron is added to TIVA.

Enrollment: 100 patients

Sex: Female

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA Physical Status 1 or 2
• Elective gynaecological laparoscopic surgery of ≥ 1h duration

Exclusion criteria

• Anti-emetics, steroids, or psychoactive medications within 24 h of study initiation
• Vomiting or retching in the 24 h preceding surgery
• Cancer chemotherapy within 4 weeks or emetogenic radiotherapy within 8 weeks before study entry
• Ongoing vomiting from gastrointestinal disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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100 participants in 2 patient groups, including a placebo group

Tiva group (Group T)

Placebo Comparator group

Treatment:

Drug: Total intravenous anesthesia

TIVA plus palonosetron group (Group T+P)

Active Comparator group

Treatment:

Drug: Total intravenous anesthesia plus palonosetron