Comparison of Total Intravenous Anesthesia Methods in Spinal Surgery (TIVA)

Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Status

Completed

Conditions

Anesthesia

Study type

Observational

Funder types

Other

Identifiers

NCT06781177

2023-05/204

Details and patient eligibility

About

This study aims to compare the effects of the classical Total Intravenous Anesthesia (TIVA) method and multimodal anesthesia protocols created by adding lidocaine and ketamine infusions on postoperative pain management, opioid consumption, and surgical recovery in posterior thoracolumbar spinal fusion surgeries.

A prospective observational study was conducted with 72 patients undergoing posterior thoracolumbar spinal fusion surgeries. Patients were evenly divided into three groups: classical TIVA (propofol and remifentanil), TIVA + ketamine, and TIVA + lidocaine. Hemodynamic parameters and drug dosages were recorded during the intraoperative period, while pain scores, opioid consumption, time to first ambulation and bowel movement, as well as nausea-vomiting and sedation scores, were documented postoperatively.

Enrollment

72 patients

Sex

All

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Aged 18 years or older,
ASA classification I-III
Patients undergoing posterior thoracolumbar spinal surgery and neuromonitoring under general anesthesia

Exclusion criteria

Emergency operations
Pregnant patients
Patients with ASA classification IV or higher*
Patients allergic to morphine and local anesthetics
Patients with neurological or psychiatric disorders (on ongoing antidepressant and/or anticonvulsant therapy) Illiterate patients
Patients unable to cooperate
Extremely low or high body weight (less than 40 kg or more than 100 kg)
Chronic opioid use
Diabetes mellitus (DM) requiring insulin therapy
Chronic alcohol use
Patients with peripheral neuropathy
Patients with cardiac arrhythmias