Comparison of Tramadol, Pethidine and Morphine in the Treatment of Pain After Thoracic Surgery

Baskent University

Status and phase: Not yet enrolling; Phase 4

Conditions: Thoracic Diseases; Analgesia

Treatments: Drug: Tramadol hydrochloride; Drug: Morphine hydrochloride; Drug: Aldolan

Study type: Interventional

Funder types: Other

Identifiers

NCT06172920

KA23/137

Details and patient eligibility

About

Comparison of analgesic effects of tramadol, aldolan and morphine under thoracic surgery

Full description

Thoracotomy is one of the most painful surgical procedures known, and severe pain is encountered in 21-67% of patients after thoracotomy. The most important causes of this pain arise from the bone structures of the thoracic wall, damage to the costal joint junctions, stretching of the ligaments, rib fractures, and damage to the intercostal nerve and major muscles. Another factor that causes pain after thoracotomy is the chest tubes placed in the thorax to provide drainage (1).

As a result of this pain caused by loss of tissue and pulmonary reserve, effective coughing and decreased chest expansion can lead to serious complications such as atelectasis, ventilation/perfusion mismatch, hypoxemia, immobilization, thromboembolism and infection. These complications are associated with increased morbidity and mortality in thoracic surgery (2).

Ensuring pain management in patients undergoing thoracotomy is important in terms of reducing postoperative complications, ensuring early mobilization and increasing patient comfort. Since there is no single source that causes pain after thoracotomy, pain must be controlled at all levels. For this reason, a multimodal approach using pharmacological and non-pharmacological techniques is preferred in analgesia after thoracotomy. This approach reduces drug side effects along with the consumption of analgesics. Opioids and nonsteroidal anti-inflammatory drugs are used in pharmacological analgesia.

In our study, the investigators aim to compare the effects of tramadol, pethidine and morphine using intravenous patient-controlled analgesia in the treatment of postoperative pain in elective thoracic surgery.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Having non-urgent thoracic surgery
• over 18 years old
• Being in group I-III according to the American Society of Anesthesiologists (ASA) classification
• Not have allergies to the drugs to be used (volunteers with diseases that prevent the use of drugs will not be included in the study
• regardless of gender

Exclusion criteria

. Have allergies to the drugs to be used

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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45 participants in 3 patient groups

Tramadol

Active Comparator group

Description:

Tramadol receiving group

Treatment:

Drug: Tramadol hydrochloride

Aldolan

Active Comparator group

Description:

Aldolan receiving group

Treatment:

Drug: Aldolan

Morphine

Active Comparator group

Description:

Morphine receiving group

Treatment:

Drug: Morphine hydrochloride