Comparison of Transfers of Fresh and Thawed Embryos in Patients With Prior Failed Embryo Transfer Cycles

Fertility Center of Las Vegas (FCLV)

Status: Withdrawn

Conditions: Subfertility; Infertility

Treatments: Procedure: Fresh embryo transfer; Procedure: Embryo cryopreservation

Study type: Interventional

Funder types: Industry

Identifiers

NCT00736177

SAIRB-08-0012

Details and patient eligibility

About

This study seeks to determine if patients with a history of failed fresh embryo transfer(s) will have increased success rates with embryo cryopreservation and subsequent thawed embryo transfer when compared to fresh embryo transfer.

Full description

Implantation failure remains a significant problem in cycles of in vitro fertilization (IVF). Patients with a history of implantation failure in fresh autologous cycles have been shown have reduced chance of success in subsequent fresh autologous cycles. A potentially frequent cause of implantation failure is reduced endometrial receptivity following ovarian stimulation, perhaps due to the effects of supraphysiologic hormone levels on endometrial development. Therefore, such patients may have a greater chance of success if all of their embryos are cryopreserved for use in a subsequent cycle in which endometrial development can be more carefully controlled, absent the effects of ovarian stimulation. Therefore this study compares success rates in cycles of fresh embryo transfer and cycles with transfer of frozen-thawed embryos.

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18 to 40 years
• Cycle day 3 FSH less than 10 IU/l
• At least 8 antral follicles
• At least one previous autologous embryo transfer cycle that did not result in ongoing pregnancy at 10 weeks.

Exclusion criteria

• Embryo biopsy
• Any prior fresh embryo transfer that resulted in live birth

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

0 participants in 2 patient groups

Control

Active Comparator group

Description:

Patients in the control group will undergo conventional IVF cycles with fresh blastocyst transfer.

Treatment:

Procedure: Fresh embryo transfer

Test group

Experimental group

Description:

Patients in the Test group will have their embryos cryopreserved for transfer in a second cycle.

Treatment:

Procedure: Embryo cryopreservation